Excess taurine side effects11/5/2023 The purpose of this study was to investigate the effect of dietary taurine supplementation on plasma, liver lipid concentrations in ovariectomized rats fed calcium-deficient diet. However, the effect of taurine in an ovariectomized animal model has not been studied in the calcium deficient rats. Korean women on average consume only about one-third of their RI for calcium ( Ministry for Health Welfare and Family Affairs, 2005). The average US diet contains only 600 mg calcium a day and thus falls far below the recommended intakes ( Nieves, 2005). The effect of taurine on plasma lipids and coronary heart disease has been the subject of extensive research. Since high serum cholesterol is one of the major risk factors for atherosclerosis and coronary heart diseases, taurine is thought to prevent the development of atherosclerosis. Keywords: Taurine, lipids, Ca deficient, OVX These results indicate that taurine may have some beneficial effects on hypercholesterolemia and hypertriglyceridemia in OVX rats fed calcium-deficient diet. Therefore, in this study, we examined whether taurine also prevented hypercholesterolemia induced by ovarian hormone deficiency in ovariectomized rats when they were fed a calcium-deficient diet. Concentrations of plasma total cholesterol, triglyceride, LDL-cholesterol were significantly lower in the taurine fed group of OVX rats fed Ca deficient diet, while HDL-cholesterol concentration was increased in the taurine fed group. There were no significant differences in body weight gain and food intake between the control and taurine group within Sham and OVX groups, but body weight gain, food intake, and food efficiency ratio was higher in the OVX group. LDL-cholesterol concentrations were estimated with the equation of Friedewald et al. Plasma and liver lipids were determined by using commercial kits. All rats were fed on calcium-deficient diet and deionized water ad libitum for 6 weeks. Each rat group was further divided into the control diet and the taurine supplemented (2.0 g/100 g diet) diet group. One group was OVX and the other group received a sham operation (Sham). Forty female Sprague-Dawley rats were divided into two groups. It therefore seemed desirable to find out whether the beneficial effect of taurine on OVX rats fed calcium-deficient diet could also be reproduced. Taurine supplementation has been shown to have an effect on lowering blood lipids in ovariectomized (OVX) rats.
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